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The D-Retro-Inverso modification (using D-amino acids in reverse sequence) provides resistance to proteolytic degradation while maintaining the ability to interfere with the target protein interaction
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GHK-Cu, in contrast, delivers copper(II) ions to metalloenzymes such as lysyl oxidase (critical for collagen and elastin cross-linking), superoxide dismutase (antioxidant defense), and cytochrome c oxidase (mitochondrial respiration)
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